Open AccessTGF-beta1 in breast cancer-estrogen regulation
Author(s) -
Nataša TodorovićRaković,
Vesna Ivanović,
A Miroslav Demajo,
B Nesković,
Z. Nešković-Konstantinović,
Ksenija Kanjer,
Milan Markićević,
Dragica NikolićVukosavljević
Publication year - 2002
Publication title -
archive of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.104
H-Index - 13
eISSN - 1450-9520
pISSN - 0354-7310
DOI - 10.2298/aoo0203164t
Subject(s) - estrogen , breast cancer , transforming growth factor , cytokine , medicine , cancer , phenotype , estrogen receptor , oncology , endocrinology , cancer research , biology , gene , biochemistry
TGF-beta1 is a pluripotent cytokine with diverse effects in the normal development of mammary glands, and in the development of malignant tumors of the breast. The aim of the study was to determine the levels of TGF-beta1 in the group of advanced breast cancer, in which increased TGF-beta1 levels were most likely to be expected. TGF-beta1 levels were also compared with estradiol levels. Our results suggested that TGF-beta1 synthesis may be regulated by estrogen or anti-estrogen through ER. Finding of increased TGF-beta1 levels, due to its possible role in predicting invasive phenotype in later phases of tumor progression, may indicate the tendency of tumor tissue towards autonomy