Experimental Trichinellosis in rats: Peritoneal macrophage activity | Zendy

Alisa GrudenMovsesijan | Zendy; Ljiljana SofronićMilosavljević | Zendy

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Experimental Trichinellosis in rats: Peritoneal macrophage activity

Author(s) -

Alisa GrudenMovsesijan,

Ljiljana SofronićMilosavljević

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1001015g

Subject(s) - trichinella spiralis , mannose receptor , macrophage , biology , immune system , trichinella , parasite hosting , immunology , receptor , mannose , microbiology and biotechnology , helminths , biochemistry , world wide web , computer science , in vitro

The influence of Trichinella spiralis infection on macrophage activity in rats during the first 28 days of infection was examined by measuring the production of NO and IL-6, as well as the expression of mannose receptor on the surface of peritoneal macrophages. During the course of a dynamic shift in the 3 life-cycle stages of the parasite, intermittent variations in NO production were observed but ended with increased values that coincided with the highest values for IL-6 release in the final, muscle phase of infection. No change in mannose receptor expression was observed during the course of infection. These results confirm that the Trichinella spiralis infection provokes changes in macrophage activity that could influence not only the course of the parasitic disease but also the overall immune status of the host

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