Open AccessMaternal sirolimus therapy and fetal growth restriction
Author(s) -
Sangay Tshering,
Namkha Dorji,
Sonam Youden,
Dorji Wangchuk
Publication year - 2021
Publication title -
archive of clinical cases
Language(s) - English
Resource type - Journals
ISSN - 2360-6975
DOI - 10.22551/2021.31.0802.10180
Subject(s) - sirolimus , fetus , pi3k/akt/mtor pathway , epigenetics , intrauterine growth restriction , pregnancy , fetal growth , adverse effect , medicine , obstetrics , signal transduction , biology , microbiology and biotechnology , biochemistry , genetics , gene
Fetal growth restriction associated with continued maternal sirolimus therapy in pregnancy has not been reported. We hereby present a case of maternal sirolimus therapy resulting in fetal growth restriction and propose a multi-hit model. This hypothetic model is based on inhibition of mTOR signaling pathway and epigenetic modulation. This case report adds to the paucity of literature on continued monotherapeutic maternal sirolimus in pregnancy and its adverse fetal effects.