Open AccessDevelopment and in vitro study of Metronidazole loaded cross linked sodium alginate and gellan gum microspheres
Author(s) -
Sudipta Das,
Rahul Pan,
Rimi Dey,
Mamata Ghosh
Publication year - 2022
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v12i1-s.5345
Subject(s) - gellan gum , metronidazole , maleic anhydride , swelling , chemistry , aluminium chloride , sodium , nuclear chemistry , materials science , chromatography , chemical engineering , aluminium , organic chemistry , biochemistry , composite material , food science , polymer , copolymer , antibiotics , engineering
Formulation of metronidazole loaded trivalent ion Al+3 cross-linked and gellan gum microspheres was developed. The Metronidazole loaded microspheres were prepared taking sodium alginate, gellan gum as excipients along with maleic anhydride, aluminium chloride as cross-linking agents. The evaluation processes of prepared metronidazole microspheres were done by in-vitro release study, microscopic analysis and swelling index. Each of the formulations shows good entrapment efficiency with the maximum entrapment 85.8±5.63% was governed by the F1 formulation while F2 formulation confirms 82.3±4.72% drug entrapment. The formulations provided the controlled release delivery pattern of Metronidazole.
Keywords: Microspheres, Metronidazole, Gellan gum, Aluminium chloride, Maleic anhydride