Open AccessMapping of SARS-CoV-2 Spike Protein Evolution During the First and Second Waves of COVID-19 Infections in India
Author(s) -
Vijay Rani Rajpal,
Shashi Sharma,
Avinash Kumar,
Samantha Vaishnavi,
Apekshita Singh,
Deepmala Sehgal,
Mughdha Tiwari,
Shailendra Goel,
S. N. Raina
Publication year - 2022
Publication title -
future virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 34
eISSN - 1746-0808
pISSN - 1746-0794
DOI - 10.2217/fvl-2021-0267
Subject(s) - covid-19 , spike protein , virology , spike (software development) , sars virus , biology , coronavirus , medicine , computer science , outbreak , pathology , infectious disease (medical specialty) , software engineering , disease
Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & Methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021. Results: The study revealed 242 mutations corresponding to 207 sites. Fifty one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave). Conclusion: The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics.
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