Open AccessSINGLE-NUCLEOTIDE POLYMORPHISM OF TNFSF4 (RS2205960) OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN BANDUNG, INDONESIA
Author(s) -
ANGELA APRILIA KARYADI,
ERICA WILLY,
GABRIEL BAGUS KENNARDI,
MUHAMMAD SYAWAL PRATAMA,
Desi Reski Fajar,
Laniyati Hamijoyo,
Riezki Amalia,
Melisa Intan Barliana
Publication year - 2021
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2021.v13s4.43827
Subject(s) - genotype , genomic dna , gene , single nucleotide polymorphism , medicine , microbiology and biotechnology , immunology , biology , genetics
Objective: This study aimed to determine the genotype distribution of the TNFSF4 (Tumor Necrosis Factor Superfamily 4) gene rs2205960 in Systemic Lupus Erythematosus (SLE) patients in Bandung, West Java, Indonesia.
Methods: This was a cross-sectional study; 84 genomic DNA samples were amplified, electrophoresed, then analyzed by DNA sequencing.
Results: The genotype distribution of the TNFSF4 gene rs2205960 in SLE patients showed that from 84 DNA samples, 55 patients are GG (65.48%), 25 patients are GT (29.76%), and 4 patients are TT (4.76%).
Conclusion: Results indicate that SLE patients in Bandung have a genotype distribution of the TNFSF4 rs2205960 gene that fulfills the Hardy-Weinberg equilibrium.