Open AccessACACIA SENEGAL BARK EXTRACT IN REGULATION OF HYPOTHYROIDISM: AN EXPERIMENTAL APPROACH
Author(s) -
Dheeraj Jangid,
A. N. Purohit
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i1.28709
Subject(s) - bark (sound) , triiodothyronine , gum acacia , thiouracil , medicine , hormone , acacia , body weight , traditional medicine , endocrinology , pharmacology , thyroid , chemistry , biology , botany , food science , ecology
Objective: The objective of the present study was to evaluate the thyroid hormone stimulating efficacy of Acacia senegal (Gum Arabic) bark extract in 6-n-propyl-2-thiouracil (PTU)-induced hypothyroid albino rats.Methods: Ethanolic extract of A. senegal bark was given to PTU-induced hypothyroid albino rats at the dose of 500 mg/kg body weight. The animals were divided into control, PTU, and A. senegal bark extract treated and standard drug Eltroxin-treated groups for 60-day experimentation. The serum thyroxin levels, organ’s weight, and serum biochemistry were carried out.Results: Oral administration of A. senegal bark extract caused a highly significant increase (p≤0.001) in serum triiodothyronine (T3) and tetraiodothyronine (T4), and significant changes were also observed in organ’s weight with biochemical parameters as compared to hypothyroid albino rats and results were approximate to the standard drug Eltroxin.Conclusion: These results evaluate that ethanolic extract of A. senegal bark helps to compensate or increases the serum thyroxin level in management of hypothyroidism.