Open AccessMESENCHYMAL STEM CELLS: AN INNOVATIVE APPROACH IN PHARMACOKINETICS
Author(s) -
Seema Tripathy,
P. Mohanty
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i3.16023
Subject(s) - mesenchymal stem cell , toxicant , pharmacokinetics , genotoxicity , stem cell , mesenchyme , pharmacology , toxicity , biology , computational biology , cancer research , medicine , microbiology and biotechnology
Multipotent mesenchymal stem cells (MSCs) are special kind of stem cells which originate from mesenchyme. These cells can be used as an imperativetool to study reproductive toxicity, carcinogenicity, mutagenicity, genotoxicity, and pharmacokinetics. This novel system may reveal toxicantinducedetiology, decipher detailed understanding on molecular mechanisms of toxicants induced pathways and also enumerate the safe dose ofan investigational product. Hence, this could ultimately replace, improve or overtake current predictive models in toxicology. The particular reviewdescribes the utilization of MSCs in different field of toxicological and pharmacological research.Keywords: Mesenchymal stem cells, Toxicant, Etiology, Pharmacokinetics.