Open AccessSTUDY OF ANTIMICROBIAL, ANALGESIC AND ANTICONVULSANT ACTIVITY OF NOVEL ISATIN DERIVATIVES
Author(s) -
Sravanthi Chirra,
Venkateshwar Rao Jupally
Publication year - 2016
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2016.v9i5.11725
Subject(s) - isatin , antimicrobial , anticonvulsant , analgesic , chemistry , pharmacology , antibacterial activity , medicine , epilepsy , organic chemistry , bacteria , biology , psychiatry , genetics
Isatin is an endogenous compound and possess a wide variety of biological activities. In the present investigation, a different isatin derivatives suchas novel isatin 3-[N-(4-substituted)-hydrazinyl-3-oxo prop 1-en-2yl) benzamides and their antimicrobial, analgesic and anticonvulsant activity wasevaluated in different animal models. Antimicrobial activity by cup plate agar diffusion method. The analgesic activity was measured by Eddy’s hotplate method, and reaction time was recorded when the animals licked their for and hind paws and jumped at before 0 hr, 0.5 hr, 1 hr and 2 hrsafter administration of test drugs. 4-aminopyridine chemical induction method was employed for anticonvulsant activity. All the compounds werescreened, among the screened compounds some compounds showed antimicrobial, analgesic and anticonvulsant activity with dose-dependent effectwhen compared with the control group.Keywords: Isatin, Antibacterial, Antifungal, Analgesic, Anticonvulsant activity.