Peculiarities of development of antihypertensive action of multicomponent herbal drug Carvelis in middle-aged patients with uncomplicated arterial hypertension

Background. In more than a third of middle-aged individuals, the syndrome of arterial hypertension is determined by a combination of psychoemotional disorders and autonomic dysfunction. The purpose of the research was to study the features of psychoemotional disorders and autonomic homeostasis in 78 middle-aged patients with uncomplicated arterial hypertension and their correction by the use of Carvelis in comprehensive antihypertensive therapy. Materials and methods. The main group consisted of 40 patients with hypertension. They were prescribed a herbal complex Carvelis with standard antihypertensive treatment. Dose of Carvelis was 30 drops 3 times a day for 6 months. The second group was a control one, which included 38 hypertensive patients, who received only antihypertensive therapy. During the first visit, all patients had certain disorders of cerebral and subcortical structures, associated with signs of autonomic dysfunction, deterioration of emotional state and significant psychological stress. Results. The prescription of Carvelis for 6 months allowed achieving a decrease in blood pressure: systolic blood pressure — by 12.8 mmHg, diastolic — by 12.3 mmHg, whereas a decrease in blood pressure in the control group was less (5.0 and 5.3 mmHg, respectively) and insignificant. The antihypertensive effect of Carvelis treatment was realized through its components — hawthorn, valerian, lemon balm, motherwort. They reduced the activity of the sympathetic link of the autonomic nervous system: SDNN and RMSSD increased significantly — by 54.2 and 55.7 %, respectively, and reached physiological limits. The positive dynamics of the integrated indicators of autonomic balance and fractal index in these patients showed a more complete restoration of vagosympathetic interactions at the vascular level of homeostasis. The use of Carvelis led to the harmonization of emotional state and reduction in the level of psychological stress, which was characterized by a decrease in the index of emotional excitability by 24.5 % and anxiety — by 17,3 %, state of depression — by 21.5 % (Hospital Anxiety and Depression Scale). The analysis of systemic parameters of homeostasis regulation showed that 6-month treatment with Carvelis increased significantly the general level of bioenergy, the state of vascular regulation reserves and operative control of autonomic vascular regulation. These changes were consistent with the level of activity of the vasomotor center of vascular tone regulation, the indicators of which decreased significantly.