Open AccessComparative Efficacy of Prolactin inhibitors and PGF2 analogue in Bitches Affected with Cystic Endometrial Hyperplasia-Pyometra Complex
Author(s) -
Q. Mandhwani,
Anavil Bhardwaz,
Ranjit Aich,
Mahesh Shivhare,
Sandeep Kumar,
V. Mangrole
Publication year - 2018
Publication title -
the indian journal of veterinary sciences and biotechnology
Language(s) - English
Resource type - Journals
eISSN - 2395-1176
pISSN - 2394-0247
DOI - 10.21887/ijvsbt.v14i1.13000
Subject(s) - pyometra , cabergoline , medicine , bromocriptine , prolactin , estrous cycle , gastroenterology , gynecology , urology , uterus , hormone
The study was carried out at the Veterinary Clinical Complex, College of Veterinary Science and Animal Husbandry, Mhow and in private clinics across Indore on 30 bitches suffering from Cystic Endometrial Hyperplasia-Pyometra Complex (CEH-PC). The animals were randomly subdivided into five groups each of six bitches and treated with bromocriptine (1 g/kg POx5 days) and cabergoline (5 g/kg POx5 days) alone and in combination with cloprostenol (5 g/kg s/c on day 0, 2 and 6) (Gr II to V) together with enrofloxacin (10-20 mg/kg PO, SID×5 days) + combination of metronidazole and povidone-iodine IU (5-10 ml×3 days), the later served as routine control Gr I.The treatment response of animals was evaluated through clinical, ultrasonographical, haematological and biochemical parameters. Blood samples were collected from cephalic or saphenous vein just before treatment (day 0) and after treatment on day 6 and day 14. Treatment approach -III (cabergoline 5 g/kg POx5 days) was found to be the most effective without side effects with significant decrease in uterine luminal diameter after treatment. The results showed significant improvement in haemato-biochemical attributes in dogs affected with CEH-P complex following treatment IV and V, i.e. with use of bromocriptine and cabergoline in combination with cloprostenol as compared to other groups.