Open AccessFormulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients
Author(s) -
Manpreet Kaur,
Amit Mittal,
Monica Gulati,
Deepika Sharma,
Rajesh Kumar
Publication year - 2020
Publication title -
recent patents on drug delivery and formulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.342
H-Index - 34
eISSN - 2212-4039
pISSN - 1872-2113
DOI - 10.2174/1872211314666191224121044
Subject(s) - bioavailability , febuxostat , dissolution , pharmaceutics , microcrystalline cellulose , chemistry , chromatography , dissolution testing , dosage form , pharmacology , materials science , medicine , biopharmaceutics classification system , uric acid , cellulose , hyperuricemia , organic chemistry , biochemistry
Febuxostat is a novel, orally-administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate-limited absorption.