Open AccessModern aspects of anticonvulsant pharmacotherapy in newborns
Author(s) -
Vyacheslav Yu. Perfilev,
A. G. Miroshnichenko,
В. А. Желев,
E. V. Devald
Publication year - 2022
Publication title -
rossijskij vestnik perinatologii i pediatrii
Language(s) - English
Resource type - Journals
eISSN - 2500-2228
pISSN - 1027-4065
DOI - 10.21508/1027-4065-2022-67-1-14-20
Subject(s) - anticonvulsant drugs , anticonvulsant , medicine , pharmacotherapy , intensive care medicine , clinical trial , drug , epilepsy , pharmacology , psychiatry
Proper treatment of neonatal seizures is crucial for reducing long-term neurological disorders. None of the currently used drugs to treat neonatal seizures has sufficient evidentiary base to make an unambiguous conclusion about its effectiveness. There are no results of large-scale studies that allow choosing an anticonvulsant drug for starting therapy and an alternative to it, in case the drug of choice is ineffective. The review summarizes the data on the effectiveness of anticonvulsants of different pharmacologic classes and considers their benefits, drawbacks, and possible mechanisms of variability in effectiveness when used in newborns. The review also analyzes approaches to the duration of the anticonvulsant therapy and discusses the problems and prospects of clinical trials for increasing the effectiveness and safety of anticonvulsant therapy in newborns.