Open AccessPsoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
Author(s) -
Meron Teklu,
Philip M Parel,
Nehal N. Mehta
Publication year - 2021
Publication title -
psoriasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.066
H-Index - 4
ISSN - 2230-326X
DOI - 10.2147/ptt.s320016
Subject(s) - metabolic syndrome , psoriasis , dyslipidemia , medicine , insulin resistance , inflammation , obesity , disease , systemic inflammation , diabetes mellitus , population , immunology , endocrinology , environmental health
Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. In this review, we discuss the role of inflammation and psoriasis in cardiometabolic diseases with a focus on the metabolic syndrome and its components. We highlight the relationship between psoriasis and important cardiovascular risk factors encompassed by obesity, dyslipidemia, insulin resistance and hypertension. Furthermore, we briefly highlight literature on anti-inflammatory therapies and their impact on the components of the metabolic syndrome as well as directly quantified coronary atherosclerosis burden.