Open AccessAmino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
Author(s) -
Shagufta Naz,
Fawad Ali Shah,
Humaira Nadeem,
Sadia Sarwar,
Zhenghuai Tan,
Muhammad Imran,
Tahir Ali,
Jinbo Li,
Shupeng Li
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s297013
Subject(s) - docking (animal) , chemistry , dpph , cisplatin , in vitro , ic50 , cell culture , antioxidant , pharmacology , cell growth , biochemistry , biology , medicine , nursing , chemotherapy , genetics
The development of resistance to available anticancer drugs is increasingly becoming a major challenge and new chemical entities could be unveiled to compensate this therapeutic failure. The current study demonstrated the synthesis of 2-aminothiazole [ S3 ( a-d ) and S5 ( a-d )] and 2-aminopyridine [ S4 ( a-d ) and S6 ( a-d )] derivatives that can target multiple cellular networks implicated in cancer development.