Open Access<p>Anti-Proliferative and Apoptosis-Promoting Effect of microRNA-125b on Pancreatic Cancer by Targeting NEDD9 via PI3K/AKT Signaling</p>
Author(s) -
Yuzheng Xue,
Zhong Yao,
Tielong Wu,
Yingyue Sheng,
Yuanyuan Dai,
Lingling Xu,
Chuanqing Bao
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s227315
Subject(s) - pi3k/akt/mtor pathway , apoptosis , microrna , protein kinase b , pancreatic cancer , cancer research , chemistry , medicine , cancer , biochemistry , gene
The expression of microRNA-125b (miR-125b) is low in a variety of cancers, including gastric, lung, bladder, thyroid, and esophageal cancers. However, its specific mechanism in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study is aimed to explore the role of miR-125b in PDAC.