Corneal epithelial toxicity of antiglaucoma formulations: in vitro study of repeated applications | Zendy

Barbara De Servi | Zendy; Marisa Méloni | Zendy; G.M. Cattaneo | Zendy

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Corneal epithelial toxicity of antiglaucoma formulations: in vitro study of repeated applications

Author(s) -

Barbara De Servi,

Marisa Méloni,

G.M. Cattaneo

Publication year - 2012

Publication title -

clinical ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 56

eISSN - 1177-5483

pISSN - 1177-5467

DOI - 10.2147/opth.s35057

Subject(s) - benzalkonium chloride , irritation , medicine , h&e stain , toxicity , viability assay , ophthalmology , andrology , pharmacology , pathology , in vitro , staining , immunology , chemistry , biochemistry

By using a biologically relevant and sensitive three-dimensional model of human corneal epithelium and multiple endpoint analysis, assessment of the potential for eye irritation and long-term compatibility of four registered ophthalmological preparations, ie, Timolabak(®), Timoptol(®), Nyogel(®), and Timogel(®), was performed. This approach enables classification of the potential for irritation, discriminating between mildly irritant and non-irritant ocular substances.

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