Open AccessPotential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's disease
Author(s) -
Manal Fouad Ismail,
Aliaa Nabil ElMeshad,
Neveen A. Salem
Publication year - 2013
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s39232
Subject(s) - rivastigmine , disease , pharmacology , medicine , alzheimer's disease , therapeutic effect , dementia , donepezil
To sustain the effect of rivastigmine, a hydrophilic cholinesterase inhibitor, nanobased formulations were prepared. The efficacy of the prepared rivastigmine liposomes (RLs) in comparison to rivastigmine solution (RS) was assessed in an aluminium chloride (AlCl(3))-induced Alzheimer's model.
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