Open AccessASSOCIATION BETWEEN THE RS801460-POLYMORPHISM IN THE SRA1 GENE AND THYROID NODULES AMONG UKRAINIAN WOMEN WITH PROLIFERATIVE TYPE OF BENIGN BREAST DYSPLASIA WITHOUT ATYPIA
Author(s) -
Ivan Lukavenko,
Aliona Kolnoguz,
Mykola Kyrychenko,
Олександр Васильович Атаман,
V. Yu. Harbuzova
Publication year - 2020
Publication title -
shìdnoukraïnsʹkij medičnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2664-4231
pISSN - 2663-5909
DOI - 10.21272/eumj.2020;8(4):377-382
Subject(s) - biology , pathogenesis , gene , thyroid , hormone , cancer research , genetics , endocrinology , immunology
As it was revealed, the greater part of the human genome is represented by non-coding sequences. They also include long non-coding RNAs (lncRNAs). SRA1 is one of its representatives. This lncRNA affects steroid hormones receptors by activating their transcriptional activity. Thereby, SRA1 can be involved in pathogenesis of steroid-responsive tissues tumors.