Open AccessSynthesis of some Heterocyclic Compounds Derived from
Author(s) -
Mohammed A. AlIraqi,
Maysa’a K. Shaker Al-Mala Kodair
Publication year - 2013
Publication title -
mağallaẗ baġdād li-l-ʿulūm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 6
eISSN - 2411-7986
pISSN - 2078-8665
DOI - 10.21123/bsj.10.3.525-536
Subject(s) - thiourea , toluene , chemistry , acetophenone , thiazole , thiazoline , yield (engineering) , sulfonyl , chloride , organic chemistry , medicinal chemistry , catalysis , materials science , alkyl , metallurgy
The 4-(?-bromo acetyl)-4?-toluene sulfonanilide (2) was used as key intermediate to synthesize new heterocyclic compounds. This bromo compound was synthesized via sulfonation of amino group of p-amino acetophenone using Hinsburg method with 4-toluene sulfonyl chloride to form 4-acetyl-4?-toluene sulfonanilide (1) which is used as a starting material in this work. This compound was brominated to yield compound (2) which is used as a precursor to synthesize new five and seven membered heterocyclic compounds such as substituted 1,3-oxazoles (3,4), 1,3-thiazole derivatives (5-7), thiourea compounds (8a,b), 1,3-Thiazoline-2-thione compounds (9a-f) and 1,2,5-triazepine compounds (11a-d).The synthesized compounds were identified depending upon physical, FT-IR and UV spectroscopic data.