Open AccessCharacterization of microvessels and parenchyma in in-line phase contrast imaging CT: healthy liver, cirrhosis and hepatocellular carcinoma
Author(s) -
Jinghao Duan,
Chunhong Hu,
Qingtao Qiu,
Jing Zhang,
Hao Meng,
Keqiang Wang,
Huajiang Dong,
Hong Wei,
Yong Yin
Publication year - 2019
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims.2019.06.12
Subject(s) - cirrhosis , hepatocellular carcinoma , medicine , radiology , nuclear medicine , ex vivo , parenchyma , radiography , liver parenchyma , liver cancer , liver disease , pathology , in vivo , biology , microbiology and biotechnology
Hepatocellular carcinoma (HCC) is a cancer with a poor prognosis, and approximately 80% of HCC cases develop from cirrhosis. Imaging techniques in the clinic seem to be insufficient for revealing the microstructures of liver disease. In recent years, phase contrast imaging CT (PCI-CT) has opened new avenues for biomedical applications owing to its unprecedented spatial and contrast resolution. The aim of this study was to present three-dimensional (3D) visualization of human healthy liver, cirrhosis and HCC using a PCI-CT technique called in-line phase contrast imaging CT (ILPCI-CT) and to quantitatively evaluate the variations of these tissues, focusing on the liver parenchyma and microvasculature.