Open AccessEffect of Lochein on liver metabolism under acute intoxication caused by the paracetamol and <i>D</i>-galactosamine
Author(s) -
A. N. Sokolovskaya
Publication year - 2006
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2006-3-48-52
Subject(s) - bilirubin , galactosamine , chemistry , glucuronic acid , metabolism , alkaline phosphatase , acetaminophen , liver injury , medicine , biochemistry , drug metabolism , pharmacology , endocrinology , enzyme , polysaccharide , glucosamine
Influence of original hepatoprotector lochein in comparison with influence of reference drug silimarin on metabolism of liver under acute intoxication caused in rats by the paracetamol or D -galactosamine was investigated in the given study. Lochein decreased more effective than silimarin manifestations of hepatotoxicity of paracetamol and D -galactosamine, contributed to recovery of basic functions of liver: it decreased blood activity of aminotranferases, alkaline and acid phosphatases, concentration of common bilirubin, activated its binding with glucuronic acid, brought protein and lipids to normal levels, prevented formation of products of lipid peroxidationproducts in the liver.