Open AccessSynthesis of 2,2'-Bis-7-Substituted-[1,3,4]Thiadiazolo-[2,3-B]Quinazolin-5-one and Screened for Analgesic Activity
Author(s) -
Dipu Kakoty,
B. Shivakumar,
Kamal Nayan
Publication year - 2019
Publication title -
pharmaceutical and biosciences journal
Language(s) - English
Resource type - Journals
ISSN - 2582-0540
DOI - 10.20510/ukjpb/7/i2/185544
Subject(s) - analgesic , chemistry , in vivo , stereochemistry , combinatorial chemistry , medicinal chemistry , pharmacology , medicine , biology , microbiology and biotechnology
A series of 2,2'-bis-7-substituted-[1,3,4]thiadiazolo-[2,3-b]quinazolin-5-one were synthesized by action of 3-amino-2-mercaptoquinazolinone-4(3H)-one. By the analytical and spectral properties of IR, H1NMR and Mass, newly synthesized compounds are characterized. The present new series of compounds have been subjected to the analgesic (in vivo) activities by standard methods. Results of the activities reveals that, none of the compounds exhibited good to significant analgesic activities.