Open AccessMast cell degranulation in periodontal disease from HIV-infected individuals
Author(s) -
Giovanna Ribeiro Souto,
Alessandro Oliveira De Jesus,
Takeshi Kato Segundo,
Paôlla Freitas Perdigão,
Fernando Oliveira Costa,
Ricardo Alves Mesquita
Publication year - 2019
Publication title -
brazilian journal of oral sciences/brazilian journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 11
eISSN - 1677-3225
pISSN - 1677-3217
DOI - 10.20396/bjos.v18i0.8656600
Subject(s) - degranulation , gingivitis , medicine , periodontitis , chronic periodontitis , immunology , mast cell , human immunodeficiency virus (hiv) , dentistry , receptor
Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.