Open AccessCobalamin deficiency and pathogenesis of neurological disorders
Author(s) -
А. В. Перешеин,
С. В. Кузнецова,
Т. Е. Потемина
Publication year - 2021
Publication title -
vestnik medicinskogo instituta «reaviz». reabilitaciâ, vrač i zdorovʹe/vestnik medicinskogo instituta "reaviz". reabilitaciâ, vrač i zdorovʹe
Language(s) - English
Resource type - Journals
eISSN - 2782-1579
pISSN - 2226-762X
DOI - 10.20340/vmi-rvz.2021.6.phys.1
Subject(s) - cobalamin , pathogenesis , central nervous system , disease , medicine , nervous system , neuroscience , vitamin b12 , immunology , biology
The brief review deals with the specific value of B vitamins for the nervous system, the mechanisms of transport and metabolic functions of cobalamin, pathogenetic theories related to vitamin B 12 deficiency such as canonical biochemical theory and the theory of dysregulation of cytokines and growth factors; the hyperhomocysteinemic component of cerebral small vessel disease as one of the most common types of degenerative disorders of the central nervous system has been mentioned; the types of disorders associated with cobalamin deficiency that underlie its neurological manifestations have been described.