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EFFECTS OF MESOLIMBIC DOPAMINE DEPLETION ON RESPONDING MAINTAINED BY COCAINE AND FOOD
Author(s) -
Caine S. Barak,
Koob George F.
Publication year - 1994
Publication title -
journal of the experimental analysis of behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.75
H-Index - 61
eISSN - 1938-3711
pISSN - 0022-5002
DOI - 10.1901/jeab.1994.61-213
Subject(s) - nucleus accumbens , dopamine , reinforcement , self administration , mesolimbic pathway , psychology , olfactory tubercle , pharmacology , neuroscience , anesthesia , ventral tegmental area , medicine , dopaminergic , social psychology
The hypothesis that mesolimbic dopamine is selectively involved in cocaine reinforcement was investigated in the rat. Animals were trained under a multiple schedule in which responding was reinforced by intravenous cocaine (0.75 mg/kg/injection) or food (45‐mg pellets) under fixed‐ratio 15 schedule requirements in alternate 30‐min components of a 2‐hr daily session. Infusion of the catecholaminergic neurotoxin 6‐hydroxydopamine, but not the vehicle solution, into the region of the nucleus accumbens and olfactory tubercle produced selective reductions in cocaine self‐administration without significantly altering responding maintained by food within the same sessions. This effect was reproduced in intact animals by substituting saline for cocaine in the self‐administration component. These results support the hypothesis that the reinforcing effects of cocaine are dependent upon mesolimbic dopamine and demonstrate that cocaine self‐administration can be disrupted in animals without altering behavior maintained by a nondrug reinforcer.