Open AccessDEPENDENCE OF GRAVITY OF LIVER DISEASE FROM REPLICATIVE ACTIVITY OF VIRUS HEPATITIS B AND D
Author(s) -
M. Abdukadirova,
A. A. Khikmatullaeva,
Muhlisa Hodjaeva,
Naiying Kan
Publication year - 2018
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.18821/1560-9529-2019-23-5-234-238
Subject(s) - cirrhosis , viral hepatitis , liver disease , hepatitis b virus , virus , hepatitis d virus , viral load , virology , hepatitis b , stage (stratigraphy) , disease , hepatitis , hepatocellular carcinoma , hepatitis d , medicine , rna , cytolysis , immunology , biology , gene , paleontology , biochemistry , hbsag , cytotoxic t cell , in vitro
The article is devoted to the study of the connection between the replicative activity of HBV DNA and HDV RNA with the formation of CP at all stages of development of chronic hepatitis of viral nature, evidence that a high level of HBV DNA is a pronounced predictor of liver cirrhosis (LC) progression. The purpose of the study is to study the dependence of the severity of liver damage on the replicative activity of the hepatitis B virus and D. Materials and methods. The study included 67 patients with cirrhosis of the liver in the outcome of viral hepatitis B and 140 patients with an outcome of cirrhosis against the background of chronic hepatitis B + D. The clinical stage of LC was determined according to the Child-Puy classification. Results. A direct link has been established between the increase in the viral load of HBV DNA and HDV RNA with the duration of the disease. A tendency was revealed to increase the severity of the disease in patients with LC of viral etiology with an increase in viral load. The biochemical indices of blood showed a tendency to an increase in the level of cytolytic enzymes against the background of high replicative activity of HBV DNA and HDV RNA. The conclusion. Thus, a high level of HBV DNA is a pronounced predictor of the progression of LC at all stages of the pathological proces