Open AccessMethods to monitor the therapy oral anticoagulants: the current problems.
Author(s) -
Jovan P. Antović,
T B Kondratieva
Publication year - 2018
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2018-96-2-101-105
Subject(s) - medicine , atrial fibrillation , intensive care medicine , gold standard (test) , stroke (engine) , venous thrombosis , thrombin generation , thrombosis , surgery , cardiology , thrombin , engineering , mechanical engineering , platelet
Oral anticoagulants antivitamin-K (ОАС - AVК) are highly effective drugs that prevent the development of venous thrombosis, stroke in atrial fibrillation. Routine monitoring is not recommended for DOAC. If measurements are necessary LC-MS/MS is the gold standard. The classical coagulation assays, PT-INR and aPTT, have no or very limited utility. The absence of the ability of simple laboratory tests in emergent or urgent surgery or procedures still remains unresolved.