Open AccessArterial hypertension and Alzheimer’s disease. Prologue to neurodegeneration
Author(s) -
V. Yu. Lobzin,
К. А. Колмакова,
А. Ю. Емелин,
С. Н. Янишевский
Publication year - 2019
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2019-25-2-122-133
Subject(s) - glymphatic system , dementia , medicine , disease , neurodegeneration , cognition , blood pressure , cognitive decline , cognitive impairment , alzheimer's disease , neuroscience , psychology , cardiology , psychiatry , cerebrospinal fluid
Cognitive impairment is a global medical and social problem. Alzheimer’s disease (AD) is the most common disease leading to the development of cognitive impairment and dementia. Arterial hypertension (HTN) is considered to be the strongest risk factor for the development of both vascular dementia and AD. Recent studies have demonstrated the importance of the glymphatic system in removing β-amyloid from the brain through the perivascular Virchow–Robin spaces. The interest is that the adequate functioning of the glymphatic system mainly depends on the level of blood pressure during the day and the quality of sleep. In this article, we will consider the main mechanisms of the HTN influence on the glymphatic system, brain substance-related damage and the development of cognitive impairment.