Open AccessStatins in the treatment of chronic heart failure: Beyond the hypolipidemic effects
Author(s) -
О. М. Драпкина,
О. Н. Корнеева,
Л. О. Палаткина,
В. Т. Ивашкин
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-1-11-17
Subject(s) - medicine , heart failure , pathogenesis , clinical trial , mechanism (biology) , disease , cardiology , intensive care medicine , coronary heart disease , epistemology , philosophy
Despite our knowledge about pathogenesis, clinical characteristics and treatment, chronic heart failure (CHF) remains widespread disease with poor prognosis. However, there is not a common opinion whether statins are reasonable in patients with CHF. The data about efficiency and safety of statins are contradictory and demand evidences due to regular exclusion of patients with CHF from the majority of clinical trials of statins. The reduction of the level of low-density lipoproteins is not the unique mechanism of favourable effect of statins in patients with CHF, therefore, their pleiotropic effects are considered very important.