Open AccessEfficacy and Safety of Combined Treament with Ivabradine and Metoprolol in Patients with Stable Angina Pectoris – a Systematic Review
Author(s) -
S R Gilarevskii,
Elena Viktorovna Lantsova,
А А Акимов
Publication year - 2020
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.2020.11.n1357
Subject(s) - ivabradine , metoprolol , tolerability , medicine , angina , cardiology , metoprolol tartrate , heart rate , observational study , unstable angina , adverse effect , coronary heart disease , blood pressure , myocardial infarction
This article presents results of a systematic review, which was designed for evaluating the effect of combination treatment with ivabradine and metoprolol on heart rate, frequency of angina attacks, frequency of using short-acting nitrates, and angina severity. The analysis included data from three large observational studies on efficacy of the ivabradine and metoprolol tartrate combination in patients with chronic angina. Results of the analysis supported the efficacy of the metoprolol and ivabradine combination in clinical practice, which provided effective decreases in the heart rate, frequency of angina attacks, requirement for short-acting nitrates, and alleviation of angina severity. The studies demonstrated good tolerability of this treatment.