Open AccessSOME ASPECTS OF THE PATHOGENESIS OF ISCHEMIC-HYPOXIC LESIONS OF THE CENTRAL NERVOUS SYSTEM IN NEWBORNS
Author(s) -
L.V. Ledyaikina,
Л. А. Балыкова,
Svetlana Vasilyevna Garina,
О. Н. Солдатова,
A A Tolkunova,
A A Stradina,
A. V. Gerasimenko
Publication year - 2015
Publication title -
samarskij naučnyj vestnik
Language(s) - English
Resource type - Journals
eISSN - 2782-3016
pISSN - 2309-4370
DOI - 10.17816/snv20152133
Subject(s) - hypoxia (environmental) , medicine , central nervous system , etiology , physiology , fetus , pathogenesis , bioinformatics , pregnancy , pathology , biology , chemistry , organic chemistry , oxygen , genetics
The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of the most relevant at the monent. The leading cause of perinatal morbidity and mortality continue to remain hypoxic-ischemic brain damage the fetus and newborn. Ischemic-hypoxic damage of the central nervous system (CNS) is the most dangerous and prognostic significance. They often fatal and takes a leading role in the future of children and maladjustment of severe disabling diseases. Introduction of innovative medical technologies in health care practice greatly enhances the study of the causes of many diseases and abnormalities in newborns and helps to clarify the etiology, pathogenetic mechanisms, clinical and morphological structure, as well as typical for different gestational age localization of brain damage. It is shown that the generalized disorder of lipid metabolism with the development membranodestruktive processes is closely correlated with the severity of hypoxic-ischemic lesions of the central nervous system. It was found that infants who underwent antenatal and / or intranatal hypoxia, there are significant transformation of lipid metabolism lead to changes in the composition of lipids of blood plasma and red blood cells (with the accumulation level of chaotropic fractions phospholipid bilayer membranes of red blood cells - Lizoform phospholipids and free fatty acids). The necessity inclusion complex therapy consequences of perinatal hypoxia drugs, which have antioxidant, antihypoxic activity and the ability to regulate lipid metabolism.