Open AccessTHE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN REGULATION OF SOLID TUMORS CANCER STEM CELLS CHARACTERISTICS
Author(s) -
М Д Фармаковская,
Natalya Khromova,
V. Rybko,
Копнин Павел Борисович
Publication year - 2015
Publication title -
rossijskij bioterapevtičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 1726-9792
pISSN - 1726-9784
DOI - 10.17650/1726-9784-2015-14-4-3-8
Subject(s) - epithelial–mesenchymal transition , cancer stem cell , mesenchymal stem cell , cancer research , metastasis , cancer , phenotype , cancer cell , cell , transition (genetics) , biology , pathology , medicine , gene , biochemistry , genetics
CSCs are a tumor cell subpopulation that is a potential cause of cancer therapy resistance, recurrence and metastasis. This is the reason cscs seem a promising target for developing new approaches in anticancer treatment. Several mechanisms have been revealed that allow cancer cells to acquire CSC phenotype making malignant tumor treatment much more complicated. One of such mechanisms is a variant of epithelial-to-mesenchymal transition and e-cadherin loss, which results in cells with CSC characteristics occurring in carcinomas. The purpose of the present study is to review possible ways if cscs formation in human carcinomas.