Open AccessEvaluation of the lipid peroxidation reactions activity in middle-aged men with chronic gastritis on the background of H. pylori infection
Author(s) -
M. A. Darenskaya,
Даренская Марина Александровна,
О. В. Смирнова,
Смирнова Ольга Валентиновна,
Э. В. Каспаров,
Каспаров Эдуард Вильямович,
Lyudmila Grebenkina,
Гребёнкина Людмила Анатольевна,
Alexander Alexandrovich Sinyakov,
Синяков Александр Александрович,
Л. И. Колесникова,
Колесникова Любовь Ильинична,
С. И. Колесников,
Колесников Сергей Иванович
Publication year - 2019
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn1087
Subject(s) - lipid peroxidation , chronic gastritis , antioxidant , atrophic gastritis , superoxide dismutase , gastritis , helicobacter pylori , gastroenterology , medicine , glutathione peroxidase , glutathione , immunology , biochemistry , chemistry , oxidative stress , enzyme
Background: There is not enough information about the course of the processes of lipid peroxidation-antioxidant defense in middle-aged men who are at risk of developing gastric cancer on the Correa cascade.
Aims: To analyze of the processes of lipid peroxidation activity and antioxidant defense in men with chronic gastritis and chronic atrophic gastritis in combination with and without the presence of Helicobacter pylori.
Materials and methods: 173 middle-aged men with an established diagnosis of chronic gastritis were examined, which were divided into 4 groups: group 1 ― patients with chronic gastritis without H. pylori (n=58), group 2 ― patients with chronic gastritis in combination with H. pylori (n=61), group 3 ― patients with chronic atrophic gastritis without H. pylori (n=28), group 4 ― patients with chronic atrophic gastritis in combination with H. pylori (n=26). Evaluation of the content of parameters of the lipid peroxidation system and the antioxidant components activity using spectrophotometric research methods was carried out. For statistical analysis, the software package Statistica 7.0 (Stat Soft, USA) was used. The study was conducted during 20132015.
Results: Infection H. pylori with chronic and chronic atrophic gastritis accompanied by significant changes in the system of lipid peroxidation, and antioxidant defense components in the form of primary and accumulation of end products, insufficient activity of antioxidant enzymes ― superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reducing content of reduced glutathione. The use of an integrating factor to assess the severity of prooxidant activity confirms the development of antioxidant deficiency in patients of these groups.
Conclusions: In patients with chronic and chronic atrophic gastritis, combined with H. Pylori infection, a more pronounced progression of oxidative stress reactions and a significant lack of antioxidant factors were found in comparison with patients with these forms of gastritis without H. pylori.