Open AccessMOLECULAR BIOLOGICAL CHARACTERISTICS OF CANCER
Author(s) -
Н Е Кушлинский,
М. В. Немцова
Publication year - 2015
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v69.i1-2.934
Subject(s) - stroma , angiogenesis , biology , metastasis , cancer research , tumor microenvironment , genome instability , tumor cells , suppressor , microbiology and biotechnology , cancer cell , cancer , cell , immunology , dna , dna damage , genetics , immunohistochemistry
The review presents the main and additional features that distinguish tumor cells from normal tissue cells. They include sustained proliferative signaling, evasion from growth suppressors, resisting cell death, enabling replicative immortality, angiogenesis induction, and invasion and metastasis activation. Basis for the formation of these features is provided by tumor genome instability. Tumors are complex tissues that consist of different cell types interacting with each other as well as with normal cells. An important characteristic of tumor cells is the ability to interact with the tumor microenvironment and the formation of tumor stroma.