Open AccessACUTE AND SUBACUTE TOXIC STUDY ON MICE OF GLIPIZIDE SYNTHESIZED IN VIET NAM
Author(s) -
Thi Thoi Bui,
Dai Quang Ngo,
Van Loc Tran,
Van Chien Tran,
Thi Nga Nguyen,
Thi Thao
Publication year - 2019
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/57/1/12274
Subject(s) - glipizide , pharmacology , sulfonylurea , bioavailability , viet nam , potency , oral administration , acute toxicity , medicine , toxicity , chemistry , insulin , endocrinology , biochemistry , in vitro , economy , economics
Glipizide is a second generation of sulfonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. Glipizide is absorbed rapidly, uniformly with good mean oral bioavailability. It offers several advantages such as swift and short action, high potency and also does not accumulate in plasma on repeated oral administration. In this paper we report the acute and subacute toxicity of glipizide on BALB/c albino mice. The results showed the safety of our synthesized products.