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A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX 11 helicase
Author(s) -
Freudenreich Catherine H
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020106305
Subject(s) - helicase , replisome , timeless , dna replication , biology , dna , structural biology , genetics , circular bacterial chromosome , gene , rna , circadian rhythm , neuroscience
How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G‐quadruplex binding domain that works together with the DDX 11 helicase to facilitate replication of G4 DNA structures.
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