Open AccessMechanisms of Disease: Is Mitochondrial Function Altered in Heart Failure?
Author(s) -
Dale J. Hamilton
Publication year - 2013
Publication title -
methodist debakey cardiovascular journal
Language(s) - English
Resource type - Journals
eISSN - 1947-6094
pISSN - 1947-6108
DOI - 10.14797/mdcj-9-1-44
Subject(s) - medicine , webcast , medline , medical education , world wide web , computer science , political science , law
The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.