ANTIMICROBIAL METABOLITES FROM A MARINE-DERIVED FUNGUS

A marine fungus was separated from the surface of a marine red algae. Ethyl acetate extract of the cultivated marine fungus inhibited the growth of the pathogenic bacteria E.coli and S.aureus , and the phytopathogenic fungus C. cucurbitarum . Separation of the EtOAc extract gave four compounds, which were identified as new anthraquinonederivatives 3 and 4, and the known chrysophanol (1) and rubelin A (2) by the extensive analysis of NMR data. Compounds 1-4 inhibited the growth of the gram negative bacteria E. coli and gram positive bacteria S. aureus . Compound 3 also inhibited the fungus C . cucurbitarum . Key words: marine-derived fungus, structure elucidation, anthraquinone, antimicrobial activity