Dopaminergic control of prolactin secretion regulation (review of experimental and clinical trials)

Prolactin secretion (PRL) is under complex neuroendocrine control. in which factors of various nature are involved: neurotransmitters, biologically active neuropeptides, as well as hormones of peripheral endocrine glands. However, the dominant role belongs to dopamine, which is the most important of endogenous prolactin inhibiting substances. Convincing evidence of this was obtained after the discovery and study of the tuberoinfundibular dopaminergic system of the hypothalamus, which is a part of a complex neuroendocrine system for regulating the secretion of PRL.