Open AccessIntracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
Author(s) -
А. Е. Кратнов,
Кратнов Андрей Евгеньевич,
Е Н Лопатникова,
Лопатникова Елена Николаевна,
Alexander Andreevich Kratnov,
Кратнов Александр Андреевич
Publication year - 2012
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5512
Subject(s) - myeloperoxidase , type 2 diabetes mellitus , medicine , metabolic syndrome , diabetes mellitus , oxidative stress , endocrinology , obesity , carbohydrate metabolism , metabolism , antioxidant , superoxide , chemistry , inflammation , biochemistry , enzyme
77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased risk for T2DM positively correlated in these patients with myeloperoxidase activity,level of hydrogen peroxide within neutrophils and BMI. We observed elevation of oxygen-dependent metabolism in neutrophils formpatients with morbid obesity, accompanied with decrease in antioxidant factors, which is suggestive of oxidative stress.