Open AccessFRUITS OF SORBUS AUCUPARIA L. ARE SOURCE DRUG FOR INCREASE OF TUMORS EFFECTIVENESS CHEM-OTHERAPY
Author(s) -
Н. В. Исайкина,
Г. И. Калинкина,
Т. Г. Разина,
Е. П. Зуева,
Ольга Юрьевна Рыбалкина,
Алина Валерьевна Ульрих,
Елена Павловна Фёдорова,
Анна Борисовна Шилова
Publication year - 2017
Publication title -
himiâ rastitelʹnogo syrʹâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 6
eISSN - 1029-5151
pISSN - 1029-5143
DOI - 10.14258/jcprm.2017041839
Subject(s) - rowan , chemistry , ethanol , drug , anthocyanin , lewis lung carcinoma , food science , botany , biochemistry , biology , pharmacology , cancer , genetics , metastasis
The composition of phenolic compounds of extracts of rowanberry (Sorbus aucuparia L.) fruit, prepared with 40% ethanol and 95% acidified ethanol was studied. Differences in the content of flavonoids, including anthocyanins, and phenolic acids have been established. It was found that the most efficiently increases the antimetastatic activity of cyclophosphamide extract of rowan fungi on 95% acidified ethanol enriched with anthocyanins. The purpose of the study was to: study the effect of hydroalcoholic extracts of rowan fungi on the development of Lewis lung carcinoma and the antitumor activity of cyclophosphamide; to reveal the most effective extract containing a phenolic complex, for further study as a promising drug.