Open AccessSynthesis, Characterization and Antiviral Activity of Chrysin Derivatives
Author(s) -
P. Poorna,
K. Rama Krishna,
M. Suri Appa Rao
Publication year - 2021
Publication title -
asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23400
Subject(s) - chrysin , chemistry , virus , newcastle disease , stereochemistry , combinatorial chemistry , biochemistry , virology , flavonoid , antioxidant , biology
In this work, the isolation of chrysin (1), which is a significant constituent from hexanes concentrateof Derris scandens is reported. A progression of new 1,2,3-triazole subsidiaries of chrysin were planned,combined and assessed for their antiviral movement against newcastle disease virus (NDV) and bluetongue virus (BTV) cell lines. These synthetic derivatives have indicated great antiviral action. All thesynthesized compounds (3a to 3g) were distinguished by using nuclear magnetic resonance (NMR)and mass spectroscopic techniques. Among derivatives, 3a, 3e, 3f and 3g displayed conspicuous actionagainst NDV, then again compounds 3a, 3b, 3c, 3e, 3f and 3g showed a remarkable action againstBTV than chrysin.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom