Open AccessSynthesis and Antimicrobial Activity of 2-(4-Phenyl-2H-chromen-3-yl)-1H-benzo[d]imidazole
Author(s) -
Ramachandraiah Dasari,
Gangadhar Thalari,
Jayaprakash Rao Yerrabelly,
Prasad Rao Chitneni
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23180
Subject(s) - chemistry , antimicrobial , imidazole , ciprofloxacin , proton nmr , column chromatography , carbon 13 nmr , phenylene , organic chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry , polymer , antibiotics , biochemistry
A new series of 4-phenyl-2H-chromene-3-benzimidazoles (8a-o) were synthesized by the condensationof 4-phenyl-2H-chromene-3-carbaldehyde with o-phenylene diamines. The products were purifiedthrough column chromatography and structures of these compounds were characterized by IR, 1H &13C NMR and mass spectral data. All the final compounds were screened for their antimicrobial activityand their efficacy were matched with ciprofloxacin. Five compounds (8b, 8d, 8i, 8l and 8o) werefound to be most effective compounds of this series and with activities improved than ciprofloxacinunder the tested conditions