Open AccessMicrowave Assisted Synthesis of Quinoline Fused Benzodiazepines as Anxiolytic and Antimicrobial Agents
Author(s) -
Sheetal B. Marganakop,
Ravindra R. Kamble,
Aravind R. Nesaragi,
Praveen K. Bayannavar,
Seema Joshi,
Pramod P. Kattimani,
B. S. Sudha
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23153
Subject(s) - quinoline , chemistry , anxiolytic , antimicrobial , benzodiazepine , combinatorial chemistry , microwave irradiation , antibacterial activity , docking (animal) , pharmacology , stereochemistry , organic chemistry , bacteria , biochemistry , medicine , receptor , biology , genetics , catalysis , nursing
In the present study, an efficient, facile and green protocol for synthesis of quinoline fused1,4-benzodiazepine (4a-j) by microwave irradiated condensation of 6/7/8-substituted 3-bromomethyl-2-chloro-quinoline (3a-j) obtained from 2-chloro 6/7/8-substituted quinoline-3-carbaldehyde (1a-j)with 1, 2-phenylenediamine was developed. Surflex docking studies with K+ channel is one of thephysiological targets and inhibition, which plays a role in the pathophysiology of depression revealedthat all these compounds show consensus score in the range 2.71-3.68 indicating the summary of allforces of interaction. Further, compounds 4d, 4g and 4i exhibited potent antibacterial activity