Open AccessSynthesis and Characterization of Potential Impurities of Eltrombopag Olamine
Author(s) -
Katuroju Srinivasachary,
Chennuri Rajesh,
S. N. Tiwari,
Y. S. Somannavar,
Sailendra Kumar Nadakudity,
Krishna Murthy V. R. Moturu,
Samala Bhanuchadar,
B. Ramadevi
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.22951
Subject(s) - eltrombopag , chemistry , active ingredient , impurity , benzoates , combinatorial chemistry , stereochemistry , pharmacology , organic chemistry , medicine , platelet , immune thrombocytopenia
This work reports the feasibility of recently developed industrial viable process for eltrombopag olaminestarting from 2-bromo-6-nitro phenol and reports the identification of four potential impurities relatedto eltrombopag olamine, namely eltrombopag olamine ester (1), 2-aminophenol analogue ofeltrombopag (2), 3,3′-(2-amino-3-oxo-3H-phenoxazine-4,6-diyl dibenzoic acid (3), 2′-hydroxy[1,1-biphenyl]-3-carboxylic acid (4). These impurities are the crucial components in determining the qualityof the drug substance, eltrombopag olamine during its manufacturing. These impurities have impacton the quality of eltrombopag olamine and controlled these impurities results excellent yields of activepharma ingredient of eltrombopag olamine