Open AccessAntioxidant Activity of Piperazine Compounds: A Brief Review
Author(s) -
Shaheen Begum,
M.S. Rashida Anjum,
G. Poojitha Harisree,
N. Sivalakshmi,
P. Priyanka,
K. Bharathi
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22832
Subject(s) - piperazine , chemistry , antioxidant , benzimidazole , quinoline , ring (chemistry) , chrysin , molecule , azole , oxadiazole , organic chemistry , stereochemistry , flavonoid , antifungal , medicine , dermatology
Piperazine ring is found in several potent antioxidant molecules. Literature survey revealed that the piperazine ring has been coupled todifferent heterocyclic rings such as quinoline, pyridine, pyrazine, azole, 1,3,4-oxadiazole, 1,4-benzodioxane, pyrrolidinone, benzimidazole,pyrazine benzimidazole to obtain compounds with good antioxidant activity. It is found that the natural compounds like α-lipoic acid,methylxanthine, berberine, sarsasapogenin, chrysin, chromen-4-one, co-enzyme Q when attached to piperazine ring, antioxidant activitywas improved. In the present article, piperazine containing antioxidant molecules were reviewed.