Open AccessTannic Acid Catalyzed Green Synthesis of Functionalized Chromeno-Pyrimidine-2,5-dione/thione Derivatives
Author(s) -
J. Puvithra,
D. Parthiban
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22771
Subject(s) - tannic acid , chemistry , catalysis , thiourea , pyrimidine , organic chemistry , urea , solvent , green chemistry , coumarin , biochemistry , reaction mechanism
Diversely functionalized chromeno-pyrimidine-2,5-dione/thione compounds were synthesized bycyclocondensation of 4-hydroxy coumarin, aldehydes and urea/thiourea using tannic acid as a greencatalyst and 1:1 (EtOH:H2O) as a green solvent. Different acids were screened for their catalyticactivity of chromeno-pyrimidine-2,5-dione/thione derivatives. Tannic acid (10 mol%) was used as asuitable catalyst with increased catalytic activity. By utilizing this protocol, chromeno-pyrimidinescaffolds were prepared in acceptable to excellent yield without the use of conventional volatile organicsolvent and toxic metal catalyst. To our best of knowledge, this is the first report, in which tannic acidis utilized successfully as an eco-safe catalyst for synthesis of fused pyrimidines.