Open AccessCuSCN Catalyzed Conjugate Addition of Grignard Reagents to Substituted Coumarins with Dilithium Tetrachloromanganate
Author(s) -
Mohan B. Kale,
Shrikant B. Jagtap,
Santosh S. Devkate
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22701
Subject(s) - chemistry , regioselectivity , reagent , catalysis , magnesium , grignard reagent , yield (engineering) , manganese , dilithium , organic chemistry , conjugate , medicinal chemistry , metallurgy , ion , mathematical analysis , materials science , mathematics , deprotonation
The regioselective 1,4-addition of CuSCN catalyzed Grignard reagents to the substituted coumarinsare reported. The Li2MnCl4 reagent is used to transmetallate magnesium by manganese. It addsregioselectively to coumarins and forms 1,4-addition products with higher yield under the atmosphereof nitrogen gas and at a lower temperature