Open AccessSynthesis and Biological Evaluation of 1,3,4-Oxadiazole Fused Resveratrol Derivatives as Anticancer Agents
Author(s) -
Vema Venkata Naresh,
Y. Bharathi Kumari,
Sridhar Mussulla,
Addada Ramakrishnam Raju,
A. S. Rao
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22680
Subject(s) - chemistry , resveratrol , oxadiazole , human breast , positive control , combinatorial chemistry , carbon 13 nmr , pharmacology , stereochemistry , breast cancer , cancer , biochemistry , organic chemistry , medicine , traditional medicine
A novel target compounds (9a-j) were design and synthesized and characterized by 1H & 13C NMR, ESI-MS spectral analysis. Further, these were tested for their anticancer activity against three human cancer cell lines such as MCF-7, MDA MB-231 (breast), A549 (Lung) and adriamycin was used as positive control. Among ten compounds, two compounds like 9b and 9j were showed a significant anticancer activity compared to control drug.